Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting
نویسندگان
چکیده
منابع مشابه
Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting
In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating applications, directly targeting the central nervous system, bypassing the blood brain barrier. Its benefits include dose lowering and direct brain distribution of potent drugs, ultimately reducing systemic side effects. Recently, nasal administration of insulin showed promising results in clinical trials ...
متن کاملSurface-modified nanocarriers for nose-to-brain
In the field of nasal delivery, one of the most fascinating applications is the delivery of 20 drugs directly to the central nervous system bypassing the blood brain barrier. This approach would 21 provide a series of benefits, such as dose lowering and direct targeting of potent drugs, ultimately 22 reducing their systemic side effects. Recently, clinical trials have explored the nasal adminis...
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The objective of this study was to develop intranasal nanoemulsion and gel formulations for rizatriptan benzoate for prolonged action. Nanoemulsion formulations were prepared by constructing pseudo-ternary phase diagrams using lipophilic and hydrophilic surfactants and water. Various mucoadhesive agents were tried out to form thermo-triggered mucoadhesive nanoemulsions. Mucoadhesive gel formula...
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Background For the treatment of metabolic and neurodegenerative diseases, drug delivery to the central nervous system (CNS) has gained considerable recent interest [1,2]. But many concepts for the delivery of therapeutic agents have failed by the natural blood-brain barrier (BBB). The N2B route for drugs is able to provide an adequate alternative of CNS drug delivery -bypassing the BBB [3,4]. N...
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The transport of small molecules, peptides and proteins via the olfactory epithelium and along olfactory and trigeminal nerve pathways from the nasal cavity to the brain is very well known and clinically established for central nervous system (CNS) active drugs like oxytocin, sumatriptan or insulin. Insulin is a clinically well-established biopharmaceutical with a validated function in cognitio...
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ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2018
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics10010034